Cancer cells treated with proteasome inhibitors also upregulate autophagy [44] and knockdown of two proteasomal ubiquitin receptors, PSMD4/S5a and ADRM1, in HeLa cells promotes compensatory SQSTM1/p62-mediated autophagy that clears accumulated polyubiquitinated substrates [45]. This evidence concerns the gene ADRM1 and cancer.