MAGEA3 (MAGE family member A3)/MAGEA6 are frequently reactivated in cancer cells and bind to the TRIM28 E3 ligase, which ubiquitinates PRKAA1/AMPKα1 (protein kinase AMP-activated catalytic subunit alpha 1), promoting the degradation of AMPK and the inhibition of autophagy [135]. This evidence concerns the gene PRKAA1 and cancer.