APOE and Alzheimer disease: While age, chromosomal sex, family history, and apoE genotype remain the primary risk factors for the development of AD [154,155], there are several controllable risk factors including obesity [156,157], hyperlipidemia [158,159], hypertension [160,161,162,163], type 2 diabetes [164,165,166,167], and sedentary lifestyle [168] that can be addressed in an effort to decrease the risk of developing AD.