A synergistic effect between CFTR modulators and several antimicrobial agents commonly used in CF, including ceftazidime, tobramycin, ceftriaxone, vancomycin, trimethoprim–sulfamethoxazole, moxifloxacin, linezolid, and polymyxin B has been observed [136,138,139,151]. The gene discussed is CFTR; the disease is cystic fibrosis.