SERPINA1 and alpha 1-antitrypsin deficiency: In a very appealing article, Yusa et al. [63] show that a bi-allelic correction of a point mutation (Glu342Lys) in Human induced pluripotent stem cells (hIPSCs) of the AAT gene responsible for AATD restored the structure and function of AAT in subsequently derived liver cells in vitro and in vivo.