MT-ND4 and Leber hereditary optic neuropathy: LHON point mutations in complex I genes such as m.3460G>A, m.11778G>A, and m.14484T>C in MT-ND1, MT-ND4, and MT-ND6 genes, respectively [13], are considered the most prevalent primary LHON mtDNA mutations, as they account for 90% of LHON patients [14,15].