An elevated level of circulating CgA has been associated with almost all tumor types of the neuroendocrine system [1,5], but its sensitivity varies between 47–100% depending on tumor type (100%, in gastrinomas, ~89% in pheochromocytomas, and ~69% in nonfunctioning pNETs) [1,6,7,8]. This evidence concerns the gene CGA and neoplasm.