CGA and Renal insufficiency: In addition, many oncological and non-oncological conditions, including renal failure, non-endocrine tumors (e.g., prostate, breast, thymus, uterus, colon), chronic gastritis, and current proton pump inhibitor therapy (PPIs) decrease the specificity CgA [6,9], but CgA is the only routinely measured circulating marker in pNET.