Bahl et al. [39] and Mousa et al. [40] showed a trend toward increased risk of recurrence with higher TC and LDL-C; however, another study reported that patients with hypercholesterolemia showed lower expression of endothelial vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) than patients with normocholesterolemia, and reducing blood cholesterol can suppress tumor growth by inhibiting tumor angiogenesis [41]. This evidence concerns the gene VEGFA and familial hypercholesterolemia.