ALDH5A1 and succinic semialdehyde dehydrogenase deficiency: Since the activity of succinate semialdehyde dehydrogenase (NAD+) (SSADH) was absent or markedly reduced, along with elevated levels of SSA, DHHA and GHB, we believe that the previously described central nervous system status spongiosus in Saluki dogs should be more appropriately termed succinic semialdehyde dehydrogenase deficiency (SSADHD).