Interestingly, irradiated osteocytes can promote osteoclastogenesis through the release of HMGB1 (high mobility group box 1) followed by an elevation of the RANK-L/OPG (osteoprotegerin) levels, indicating a key role for osteocytes in IR-induced bone loss during cancer therapy [104]. The gene discussed is TNFRSF11B; the disease is cancer.