TGFB1 and airway hyperresponsiveness: Sixteen upregulated and 20 downregulated mature miRNAs, and isomiRs in sensitized rats regulate several pathways previously linked to allergic inflammation or airway hyperresponsiveness including TGF-β signaling pathway [25,26], FoxO signaling pathway [27], leukocyte transendothelial migration [28], and bacterial invasion of epithelial cells [29].