However, treatment of the rats with RA-3, especially at 100 mg/kg, effectively lowered these renal dysfunction biomarkers (Cr, 0.92 ± 0.23 mg/dL; ACE 75.5 ± 10.9 U/L; BUN 5.75 ± 0.29 mg/dL) near to the values of the normal control group (Figure 2). This evidence concerns the gene ACE and Abnormal renal physiology.