For CatS, these are several collagens, elastin, laminin-5, but also cell surface receptors, such as protease-activated receptor-2, and cell adhesion molecules such as junctional adhesion molecule B (JAM-B) and E-cadherin, which is an activity that facilitates tissue remodeling, cancer cell growth, and spreading ([4] Table 1). Here, PIMREG is linked to cancer.