Contrasting these observations, Xie et al. found ALA feeding increased post-ischemic p-AKT in a model of acute T2D but not otherwise healthy hearts [53], while acute infusion of n-3 PUFA emulsion enhances post-ischemic p-AKT and p-GSK3β in hearts from healthy mice [109]. The gene discussed is GSK3B; the disease is type 2 diabetes mellitus.