17-(2-dimethylaminoethyl) amino-17-demethoxygeldanamycin (17-DMAG), with better solubility, was developed, and was found to decrease microglial activation and to inhibit phosphorylation of IκB resulting in reduced nuclear translocation of NF-kB (p65) in a stroke model [120]. The gene discussed is NFKB1; the disease is stroke disorder.