We also review strategies to deliver AMPs topically—their covalent coupling, self-assembly, coupling to antibiotics, embedding into 3D scaffold or dressing, the use of nanotechnological platforms (i.e., organic or inorganic nanoparticles) and smart nanomaterials—as future promising technologies to deliver AMPs efficiently to the site of infection, and CRISPR-Cas are also discussed. Here, ADSL is linked to infection.