Assessment of gene expression profiles in children with severe viral-induced exacerbations of asthma/wheeze uncovered two distinct molecular phenotypes—one defined by high expression of IRF7 and a robust interferon/antiviral response and the other characterised by low IRF7 expression and upregulation of markers of TGFβ signalling and type 2 inflammation [83]. This evidence concerns the gene TGFB1 and asthma.