AKT1 and glioblastoma: In particular, EGFRvIII-containing exosomes derived from GBM cells induce several morphological and phenotypic changes in endothelial recipient cells, encompassing the activation of MAPK and Akt signaling, the increase in anchorage-independent growth capacity and changes in VEGF, Bcl-x(L), and p27 gene expression [101].