In our recent report, increasing LPP1 in MDA-MB-231 breast cancer cells decreases the levels of c-Jun and c-Fos in nuclei and suppresses the expression of AP-1 (activator protein 1) -regulated genes including MMPs (matrix metalloproteinases) and CCND1/3 (cyclin D1/D3). The gene discussed is JUN; the disease is breast carcinoma.