The formyl peptide receptor (FPR) 2 is a pattern recognition receptor that, in addition to proinflammatory, pathogen-derived compounds, also recognizes the anti-inflammatory endogenous ligand annexin A1 (ANXA1), and it has been shown that ANXA1, via FPR2, controls inflammation and bacterial dissemination during pneumococcal pneumonia by promoting host defenses, suggesting ANXA1-based peptides as a novel therapeutic strategy to control pneumococcal pneumonia [77]. Here, ANXA1 is linked to pneumococcal pneumonia.