A survey that comprised 44 single nucleotide polymorphism (SNP)s of 31 candidate genes related to the lipid metabolism among Japanese people with MetS found that - 3A < G and 553G < T (Gly185Cys) polymorphisms of Apolipoprotein A5 (APOA5), the 2052T < C (Val653Val) and 1866C < T (Asn591Asn) polymorphisms of Low-density lipoprotein receptor (LDLR), the 13989ARG (Ile118Val) polymorphism of CYP3A4 (Cytochrome P450 3A4) and the 1014T < A polymorphism of C1q and tumor necrosis factor-related protein 5 (C1QTNF5) were significantly associated with the prevalence of MetS [16]. The gene discussed is LDLR; the disease is metabolic syndrome.