On the other hand, heterozygotes (CG + GG) of LPL S447X (OR = 0.45; 95%CI, 0.21–0.95; p = 0.036) and homozygotes (SS) of PGC-1α Gly482Ser (OR = 0.26; 95%CI, 0.12–0.58; p = 0.001) were independently estimated as a protective factor for MetS. This evidence concerns the gene PPARGC1A and metabolic syndrome.