Moreover, it is underlined that the TAMs polarization status is also important, with an indication for an unfavorable prognosis when macrophages of M2 class are identified in the leukocyte infiltration (higher tumor growth, rapid progression, higher grade in the assessment of TNM, high Ki-67 proliferation index, and no expression of ER and PgR receptors) [42,43,44]. This evidence concerns the gene MKI67 and neoplasm.