CCL2 and neoplasm: Calcitriol and PRI-2191 significantly increased (p < 0.05) the concentration of chemokine CCL2 in the tumor tissue of young mice in the late stage of cancer progression (Figure 6A), while this effect was not observed in aged OVX mice, with the exception of PRI-2191 (p < 0.05) which showed an increasing impact on day 28 (Figure 6B).