Interestingly, the activation of inflammation in young mice treated with PRI-2191 and PRI-2205 analogs is Cxcr4-dependent, while in the control and calcitriol-treated groups increased expression was noted for Ccr6 and Foxo1. However, this seems to be irrelevant to the metastasis process itself, since in the later stage of cancer progression, when metastases are macroscopically present, differences in the expression of inflammation-related genes were not apparent, and also differences between young and aged OVX mice were not noted. This evidence concerns the gene FOXO1 and cancer.