CXCR4 and neoplasm: In fact, the analysis of the inflammatory markers Ccr6, Cxcr4, and Foxo1 generally showed an increase in their expression only in the initial stage of tumor progression (Figure 3) when micrometastases begin to be present in the lungs [74], which can be explained as the initial mobilization of the immune system in response to a presence of metastatic cells.