Individuals with uncontrolled diabetes (fructosamine > 286 μmol/L) also had increased serum progranulin levels (71.68±16.5 ng/mL vs. 65.05±17.3 ng/mL, P = 0.004), but stratification based on cystatin C levels revealed this difference is due to kidney disease co-morbidity (Fig 1). The gene discussed is GRN; the disease is diabetes mellitus.