CD4 and infection: Infection with multiple founder viruses resulted in lower CD4+ T cell counts in the first 5 years of infection with patients infected with multiple founder viruses reaching CD4+ T cell counts under 350 cells/mm3 faster than those infected with a single variant (Fig 2A, p = 0.001) but viral load set points were similar regardless of the multiplicity of founder variants (Fig 2B, p = 0.4).