Increased diversity of viral quasispecies as a result of multivariant infection is likely a double-edged sword; while increased diversity of TF variants might theoretically increase the breadth of the early adaptive immune response which would be expected to lead to better immune mediated viral control, the increased diversity also presents greater opportunity for CTL escape, and it is likely that the balance of these two possibilities plays a role in influencing disease outcome. Here, TF is linked to infection.