Moreover, increased frequency of tissue like memory B cells that are an exhausted phenotype alongside increased frequency of plasmablasts and the costimulatory receptor CD86 on activated B cells has been previously observed during acute HIV infection and associated with viremia [39, 45, 79], but has not been linked to any viral phenotype or to multivariant infection in the absence of higher viral load. The gene discussed is CD86; the disease is HIV infectious disease.