For example, alpha-herpesviruses are mainly associated with latent infections in neuronal cells where the interferon response may be limited due to immune privilege and constitutive expression levels of ZAP are low [20], whereas beta-herpesviruses and gamma-herpesviruses are mainly associated with latency in haematopoietic cells and are therefore under greater pressure to evade host cell IFN responses [63]. Here, IFNA1 is linked to disease arising from reactivation of latent virus.