Under P. gingivalis infection, increased TGFβ secretion and bioactivity in parallel with GARP up-regulation aggravates the oncogenic pathogenesis of P. gingivalis. We found that intervention of either GARP/TGFβ or Smads/YAP/TAZ cascades can abrogate the tumor-promoting role of P. gingivalis, highlighting the potential of eradication of P. gingivalis in combination with conventional multimodality regimens for prevention and management of ESCC. Here, TGFB1 is linked to neoplasm.