Moreover, we found that internalization of P. gingivalis potentiates invasion and metastasis of ESCC through transforming growth factor-β (TGFβ)-dependent Drosophila mothers against decapentaplegic homologs (Smads)/YAP/TAZ (Yes-associated protein YAP65 homolog/Transcriptional coactivator with PDZ-binding motif) activation, which induces EMT. The gene discussed is YAP1; the disease is esophageal squamous cell carcinoma.