YAP1 and esophageal squamous cell carcinoma: Furthermore, YAP/TAZ was required for P. gingivalis-associated oncogenic roles in ESCC because deletion of YAP/TAZ or overexpression of YAP S94A/TAZ S51A mutants abrogated the increased migration, invasion, and metastasis induced by P. gingivalis. Because of the lack of a DNA-binding domain, YAP/TAZ requires transcription factor partners to fulfill its functions.