Under P. gingivalis infection, increased TGFβ secretion and bioactivity in parallel with GARP up-regulation aggravates the oncogenic pathogenesis of P. gingivalis. We found that intervention of either GARP/TGFβ or Smads/YAP/TAZ cascades can abrogate the tumor-promoting role of P. gingivalis, highlighting the potential of eradication of P. gingivalis in combination with conventional multimodality regimens for prevention and management of ESCC. The gene discussed is TGFB1; the disease is esophageal squamous cell carcinoma.