Verteporfin, a small molecular inhibitor that disrupts YAP and TEAD interaction, significantly attenuated cell growth, invasion, metastasis, EMT, and stemness induced by P. gingivalis. These data indicate that P. gingivalis-stimulated YAP/TAZ activities are essential prerequisites for the TGFβ/Smads signaling mediated tumor-promoting function of P. gingivalis, which can be abolished by interference of YAP/TAZ nuclear accumulation. This evidence concerns the gene YAP1 and neoplasm.