Pretreatment of ESCC cells with TGFβ1-N, SB-431542, and tinidazole resulted in hyperphosphorylation of YAP/TAZ (Fig 3A) and YAP/TAZ cytoplasmic localization (Fig 3B and S3A Fig) and abolished the up-regulation of CTGF and CYR61 expression in response to P. gingivalis (Fig 3A and S3B Fig). Here, CCN2 is linked to esophageal squamous cell carcinoma.