Among factors increasing IL-8 expression in glioma patients we can distinguish: necrotic cells [13], bradykinin [12], specific protein-1 (SP-1) [18], lipopolysaccharide (LPS) [19], prostaglandin E2 (PGE2) [20], or non-toxic concentrations of cadmium [21]. This evidence concerns the gene SP1 and central nervous system cancer.