S100A8 and Cowden syndrome 1: A number of canonical pathways were related to IL-17A mediated inflammatory processes in CS, with upregulation of IL17A (4.7 fold), S100 calcium binding proteins S100A7 (psoriasin 1, 21.5 fold), S100A8 (calgranulin A, 19.9 fold) and S100A9 (calgranulin B, 21.1 fold); CCL20 (9.1 fold), CXCL6 (64.32 fold) and IL8 (13.9 fold).