Dendritic cell maturation and antigen presentation related genes were downregulated, including CD1B (-8 fold), Major histocompatibility complex (MHC) II (HLA-DOB,-2.8 fold, only in CS) MHC IA5 (HLA-5, -6 fold) and interleukin 12B and its receptor (-2 and -3 fold respectively, at 2 wpi). The gene discussed is CD1B; the disease is Cowden syndrome 1.