CDH1 and carcinoma: The recommended prophylactic treatment for carriers of germline mutations in the CDH1 gene is total gastrectomy (van der Post et al., 2015; Strong et al., 2017); bloc resection of gastric mucosa in early carcinoma is an accepted treatment in those patients who are not carriers of mutations, however, it is not enough in patients with germline mutations as the neoplasm can develop anywhere in the mucosa.