Germline mutations in E‐cadherin gene (MIM 192,090; CDH1) are associated with autosomal‐dominantly inherited cancer syndrome characterized by hereditary diffuse gastric cancer (HDGC), lobular breast cancer (BC) (Hansford et al., 2015), and in some families, cleft lip/palate (Obermair et al., 2019). This evidence concerns the gene CDH1 and Hereditary breast cancer.