These genes include IER3IP1, SAR1A, TMEM38B, PLCB4, SIN3B, ABHD5, SH3BP5, CAPG, PCOLCE2, and MN1. The first six genes from this group were down-regulated in all MPS types/subtypes while the last four genes were up-regulated in all MPS types/subtypes, indicating that there is a common pattern of expression dysregulation of these genes. This evidence concerns the gene PLCB4 and mucopolysaccharidosis.