The list of genes in which log2FC exceeds 4.0 in any MPS type/subtype includes: WISP2, RARRES2, APOE, TNFRSF11B, MMP3, CXCL8, PTGS1, WISP2, CAV1, SNX3, MMP12, CD9, COMP, TFPI2, IGFBP5, CAPG, OXTR, KRT19, CRLF1, CRIP1, and NME2 (Table 3). The gene discussed is APOE; the disease is mucopolysaccharidosis.