CD40LG and Lyme disease: For example, we reported on one patient with autoimmune hypergammaglobulinemia and respiratory symptoms, who was RT-qPCR-negative for SARS-CoV-2 in two separate samples and showed low anti-SARS-CoV-2 IgM reactivity but at the same time had detectable IgM against Lyme borreliosis, TBE, VZV, measles, and mumps.