TP53 and lung carcinoma: For instance, TP53 carries G > T/C > A transversions in smokers’ lung cancer associated with exposure to polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BaP) or A > T/T > A transversions in urothelial carcinomas associated with aristolochic acid I (AAI) exposure (Kucab et al. 2010).