Following hypoxic conditions for 48 h, HIF-1α and HIF-2α mRNA expression was decreased in normal (p = 0.014 for both) and KC-HCFs (p < 0.0001 for both), compared with controls, but HIF-1α and HIF-2α protein expression remained unchanged (p > 0.393). The gene discussed is EPAS1; the disease is keratoconus.