Piras et al. [50] evaluated the density of CD8+ lymphocytes (low, 0–20 cells/HPF; moderate, 20–100; high, >100) at the base of the tumor mass in 47 patients with Stage I and II primary cutaneous melanoma, and found that patients with high CD8+ TIL density showed longer OS than that of others (p = 0.01). This evidence concerns the gene CD8A and cutaneous melanoma.