ACTA1 and neoplasm: However, tumor vessels in glufosinate‐treated mice displayed increased vascular coverage and perfusion as shown, respectively, by an increased expression of α‐smooth muscle actin (α‐SMA) (Fig 4C), increased lectin perfusion (Fig 4D), and reduced tumor hypoxia (Fig 4E), all signs of tumor vessel normalization (Mazzone et al, 2009).