EGR1 and neoplasm: Since SRF was found to be involved in the expression of the genes controlling cell proliferation such as Fos, Junb, Fosb, and Egr1 [4], various studies have associated SRF with tumor formation and cancer metastasis but this role can be either positive, which causes tumor proliferation, or negative, which suppresses tumor cells depending on the specific pathways involved [13, 60].