While the potential prognostic significance of ST2 [18], VCAM1 [18], and ICAM1 [26] toward SOS is consistent with previous reports, association of two other biomarkers (ie, endothelial expressed TIM3 and Paneth cell expressed REG3α) with SOS is a novel observation. The gene discussed is ICAM1; the disease is spondylo-ocular syndrome.