Results of in vivo and in vitro T2DM-induced NAFLD and quercetin treatment models revealed that quercetin could alleviate the serum transaminase and IL-1β, IL-6, and TNF-α levels; recover oxidative stress; and markedly reduce T2DM-induced histological alterations and lipid accumulation of the livers, accompanied by the restoration of the increased serum total bile acid and the decreased liver total bile acid [24]. The gene discussed is TNF; the disease is type 2 diabetes mellitus.