In HFD-fed rats and FFA-induced HepG2 cells, except for the alleviation effect of KTZG on lipid accumulation and hepatic steatosis, our results showed that KTZG could regulate the expression of these lipid-related genes, upregulating PPAR-γ and Sirt and downregulating FAS and SREBP-1. Here, PPARG is linked to fatty liver disease.