CX3CR1 and arthropathy: A similar level of CX3CR1 overexpression in the slices of the synovial membrane may be partly accounted for by the similar stage of clinical development of the joint disease in both groups and also due to the appropriate preoperative regular administration of FRT to HA patients and introduction of an appropriate care program which minimizes the risk of hemarthrosis and exacerbations of joint-related manifestations [24].