CX3CR1 and hemophilia A: Therefore, considering the previous research on a preclinical rodent model of hemophilia A, it may be indirectly assumed that CX3CR1 expression could increase throughout as it was observed in the case of other inflammatory cytokines interconnected with the CX3CL1/CX3CR1 axis, such as interleukin 1 beta (IL-1β) and tumor necrosis factor alpha (TNFα) [25].