Moreover, we investigated the correlations between the global m6A content and the mRNA expression of ALKBH5, FTO, and YTHDF2 in the peripheral blood, and we found that the increased m6A contents negatively correlated with decreased mRNA expression of FTO. Although FTO was decreased and global m6A contents were increased, we did not know which mRNA that plays an important role in RA was methylated. The gene discussed is FTO; the disease is rheumatoid arthritis.