HIF1A and diabetic kidney disease: Li et al. [27] used the method of weighted gene coexpression network analysis to link the renal tubulointerstitial gene expression profile of diabetic nephropathy to eGFR values and found that there was a negative correlation between HIF-1α and eGFR, as well as samples with increased HIF-1α expression were enriched with the signaling pathways of renal fibrosis.