BRCA1 and cancer: Furthermore, knowledge of a woman’s BRCA1/2 status following a diagnosis of cancer can inform surgical decision-making, such as pursuing RR contralateral mastectomy (RRCM) or RR bilateral salpingo-oophorectomy (RRBSO), and may guide therapeutic decisions, such as platinum-based neoadjuvant chemotherapy or poly ADP-ribose polymerase inhibitors2,3.