TNF and cancer: The high density of tumor tissue infiltrated with neutrophils provides a favorable environment for cancer development by removing many inflammatory mediators such as tumor necrosis factor a (TNF-a), vascular endothelial growth factor (VEGF), interleukin-2 (IL-2), interleukin-6 (IL-6), and interleukin-10 (IL-10) [24,25].