Furthermore, the incidence of Alzheimer’s disease (AD) is higher in women than men, which is likely associated with estrogen depletion in the postmenopausal period, as estrogen regulates neurotrophin signaling and neurotransmission and protects against oxidative stress and inflammation in the brain (Brann, Dhandapani, Wakade, Mahesh, & Khan, 2007; Gurvich, Hoy, Thomas, & Kulkarni, 2018; Markou, Duka, & Prelevic, 2005; Viña & Lloret, 2010). The gene discussed is BDNF; the disease is Alzheimer disease.