ADAMTS12 and neoplasm: Figure 3 depicts the relationship between the ADAMTS molecules and tumor progression. Genes such as ADAMTS1, ADAMTS10, and ADAMTS12 were found to increase with tumor progression (P < 0.05). By analyzing the ADAMTS family of genes, we found that ADAMTS12 and ADAMTS16 had the highest mutation rate (i.e., 12%), which was mainly due to amplification and missense mutation. The lowest rate of genetic change occurred in ADAMTS6 (rate = 1.8%; Figure 4).