In this regard, there are some COVID-19 immunopathogenesis factors including granulocyte colony-stimulating factor (G-CSF), tumor necrosis factor-α (TNF-α), macrophage inflammatory protein, (MIP-1A), monocyte chemoattractant protein-1 (MCP-1), interferon gamma-induced protein-10 (IP-10), interleukin-1 (IL-1), IL-2, IL-6, IL-7, and IL-10 that can be used as detection markers in COVID-19 patients [12]. This evidence concerns the gene TNF and COVID-19.