Apoptosis (programmed cell death) and its associated signalling proteins are linked to drug discovery in cancer [1-3].Several apoptotic signalling proteins such as Bax [4], Caspase 3 [5], Cox 2 [6]and Caspase 9 [7] are known to be associated with colorectal cancer (CRC).It is of interest to study the interaction of these proteins with piperinea known drug candidate [8]. Here, CASP9 is linked to colorectal cancer.