Furthermore, multivariate analysis revealed that SMOC2 was an independent prognostic marker (HR = 0.555, P = 0.006) along with perineural invasion (HR = 1.890, P < 0.001), tumor stage (HR = 3.029, P < 0.001), and adjuvant chemotherapy (HR = 0.281, P < 0.001) (Table 3). Here, SMOC2 is linked to neoplasm.