To explore the functional roles of SMOC2 in CRCs, we screened 12 CRC cell lines and found that SMOC2 protein levels are undetectable or very low in seven cell lines, while three cell lines, includingKM12SM, HCT116 and SW1116, showed significant SMOC2 expression (Fig. 5a). This evidence concerns the gene SMOC2 and colorectal carcinoma.