In addition, we determined the prognostic impact of SMOC2 with a large number of CRC patients, and demonstrated that CRC patients with SMOC2 positivity has better clinical outcomes in both overall (P < 0.001), and recurrence-free survival rates (P < 0.001) (Fig. 4b), regardless of adjuvant chemotherapy treatment (Fig. 4c). This evidence concerns the gene SMOC2 and colorectal carcinoma.