Thus, it was shown that the expression of TMAO producing enzyme FMO3 is suppressed by insulin7; subsequently, it was shown that FMO3 knockout mice are protected from the development of hyperglycaemia, hyperlipidaemia and atherosclerosis due to the suppression of FOXO1, a transcription factor that is the main target of insulin signalling. This evidence concerns the gene FMO3 and Hyperglycemia.