APP and Alzheimer disease: In light of the deficiencies described above, the aim of our study was originally proposed to longitudinally study the dynamic change of lipid species in the APP/PS1 transgenic AD model over its lifespan from 2, 3 to 7 months old, and to monitor lipid disturbances close to the initial pathological impairment in brain of female AD mice as well as within the blood circulation, as depicted in Figure S1.