Moreover, the immunofluorescent staining (Fig. 7A) and qRT-PCR (Fig. 7B,C) results clearly showed increased production ofNLRP3, caspase-1 and IL-1β in corneal and conjunctival epithelia of DS mice, whereas their levels decreased by hADSC-Evs application. This evidence concerns the gene CASP1 and Dravet syndrome.